Sucraid (sacrosidase) Oral Solution
Sucraid is an enzyme replacement therapy that contains sacrosidase as a partial substitute for sucrase, which is one of the enzymes that is defective in individuals who have Congenital Sucrase-Isomaltase Deficiency (CSID).
Sacrosidase facilitates the breakdown of sucrose (sugar) into its constituent monosaccharide units, glucose and fructose, for absorption from the small intestine. Sucraid has been documented to help relieve the gastrointestinal symptoms associated with CSID, and as a result, help affected individuals maintain a more normal diet that includes sucrose-containing foods.
Figure 1. What you get with a prescription for Sucraid. Sucraid must be kept cold.
Proper dosing is essential for Sucraid to be effective.
The proper dosage is 1 or 2 mL (one or two full measuring scoops) with each meal or snack. Each full measuring scoop equals 1 mL. The proper dose for affected individuals weighing up to 33 lb (15 kg) is 1 mL (one full measuring scoop), and the proper dose for affected individuals weighing more than 33 lb (15 kg) is 2 mL (two full measuring scoops).
The appropriate dose of Sucraid is to be taken orally with each meal or snack, diluted with 2 to 4 ounces (60 to 120 mL) of water, milk, or infant formula. Because heat or acidity may decrease the potency of Sucraid, the diluting liquid should not be a warmed or acidic liquid such as fruit juice. It is recommended that approximately half the dose be taken at the beginning of a meal or snack, and the remainder taken during a meal or snack.
Information about CSID and Sucraid
Congenital Sucrase-Isomaltase Deficiency (CSID), also known as Genetic Sucrase-Isomaltase Deficiency (GSID), is an autosomal recessive disorder that causes a deficiency in sucrase isomaltase (SI), the enzyme responsible for the metabolism and absorption of sucrose and other sugars found in starch.
How to Diagnose CSID
The clinical diagnosis of CSID can be challenging. Here are available objective tests that can aid in your diagnosis.
Sucraid is the only FDA-approved enzyme replacement therapy that is a substitute for sucrase, the digestive enzyme that is missing or not working in patients with genetic sucrase deficiency, a major component of Congenital Sucrase-Isomaltase Deficiency (CSID). Sucraid facilitates the metabolism of sucrose into its constituent monosaccharide units, glucose and fructose, for absorption from the small intestine. Sucraid is dispensed in 118-mL translucent plastic bottles, packaged with two bottles per box. Sucraid should be taken with each meal or snack, dissolved in 2 to 4 ounces of water, milk, or infant formula.
See Important Safety Information below.
How to Order Sucraid
Could It Be CSID? with William D. Chey, MD
Join William D. Chey, MD as he reveals recent data that suggest how CSID may be an overlooked cause of unresolved GI symptoms in adults previously diagnosed with and treated for IBS-D.