Sucraid (sacrosidase) Oral Solution

The only FDA-approved enzyme replacement therapy indicated for the treatment of genetically determined sucrase deficiency, which is part of Congenital Sucrase-Isomaltase Deficiency (CSID).
About CSID

About CSID

Congenital Sucrase-Isomaltase Deficiency (CSID) also known as Genetic Sucrase-Isomaltase Deficiency (GSID).

How to Diagnose CSID

The clinical diagnosis of CSID can be challenging. Here are available objective tests that can aid in your diagnosis.

About Sucraid

About Sucraid

Sucraid is the only FDA-approved enzyme replacement therapy indicated for the treatment of CSID.

How to Order

Information on ordering Sucraid and programs to make Sucraid affordable for all patients.

What is Sucraid?

Sucraid is an enzyme replacement therapy that contains sacrosidase as a partial substitute for sucrase, which is one of the enzymes that is defective in individuals who have Congenital Sucrase-Isomaltase Deficiency (CSID).

Sacrosidase facilitates the breakdown of sucrose (sugar) into its constituent monosaccharide units, glucose and fructose, for absorption from the small intestine. Sucraid has been documented to help relieve the gastrointestinal symptoms associated with CSID, and as a result, help affected individuals maintain a more normal diet that includes sucrose-containing foods.

Sucraid Bottles

Figure 1. What you get with a prescription for Sucraid. Sucraid must be kept cold.

Proper dosing is essential for Sucraid to be effective.

The proper dosage is 1 or 2 mL (one or two full measuring scoops) with each meal or snack. Each full measuring scoop equals 1 mL. The proper dose for affected individuals weighing up to 33 lb (15 kg) is 1 mL (one full measuring scoop), and the proper dose for affected individuals weighing more than 33 lb (15 kg) is 2 mL (two full measuring scoops).

The appropriate dose of Sucraid is to be taken orally with each meal or snack, diluted with 2 to 4 ounces (60 to 120 mL) of water, milk, or infant formula. Because heat or acidity may decrease the potency of Sucraid, the diluting liquid should not be a warmed or acidic liquid such as fruit juice. It is recommended that approximately half the dose be taken at the beginning of a meal or snack, and the remainder taken during a meal or snack.

Information about CSID and Sucraid

About CSID

Congenital Sucrase-Isomaltase Deficiency (CSID), also known as Genetic Sucrase-Isomaltase Deficiency (GSID), is an autosomal recessive disorder that causes a deficiency in sucrase isomaltase (SI), the enzyme responsible for the metabolism and absorption of sucrose and other sugars found in starch.

How to Diagnose CSID

The clinical diagnosis of CSID can be challenging. Here are available objective tests that can aid in your diagnosis.

About Sucraid

Sucraid is the only FDA-approved enzyme replacement therapy that is a substitute for sucrase, the digestive enzyme that is missing or not working in patients with genetic sucrase deficiency, a major component of Congenital Sucrase-Isomaltase Deficiency (CSID). Sucraid facilitates the metabolism of sucrose into its constituent monosaccharide units, glucose and fructose, for absorption from the small intestine. Sucraid is dispensed in 118-mL translucent plastic bottles, packaged with two bottles per box. Sucraid should be taken with each meal or snack, dissolved in 2 to 4 ounces of water, milk, or infant formula.

See Important Safety Information below.

How to Order Sucraid

Click the How to Order tab above to download a Sucraid Prescription Form or call US Bioservices at 1-833-800-0122. Sucraid is only available through an exclusive specialty pharmacy provider, US Bioservices, that ships the therapy directly to the patient’s home or physician’s office.

Patient Support

The SucraidASSIST program provides patients with access to a variety of support services, including insurance assessment, financial assistance for all Sucraid patients, pharmacy services, peer support coaching, and nutrition counseling.

Watch Now

Behind the Mystery: Rare & Genetic Diseases is a special video on the balancing act of treating individuals who have CSID. It is an interview with Dr. William Treem, a highly respected pediatric gastroenterologist who has studied and treated patients with CSID for years.

QOL Medical contributed financially to the production and air time of this video, which appeared on the Lifetime Television Network. Brandi Rabon, who appears in this video, is a QOL Medical employee. Dr. William R. Treem, who also appears in this video, was a paid consultant of QOL Medical and was compensated for his time in participating in this video.

Important Safety Information for Sucraid® (sacrosidase) Oral Solution

  • Sucraid may cause a serious allergic reaction. Patients should stop taking Sucraid and get emergency help immediately if any of the following side effects occur: difficulty breathing, wheezing, or swelling of the face. Care should be taken when administering initial doses of Sucraid to observe any signs of acute hypersensitivity reaction.
  • Do not use Sucraid (sacrosidase) Oral Solution with patients known to be hypersensitive to yeast, yeast products, papain, or glycerin (glycerol).
  • Although Sucraid provides replacement therapy for the deficient sucrase, it does not provide specific replacement therapy for the deficient isomaltase.
  • Adverse reactions as a result of taking Sucraid may include worse abdominal pain, vomiting, nausea, diarrhea, constipation, difficulty sleeping, headache, nervousness, and dehydration.
  • Before prescribing Sucraid to diabetic patients, the physician should consider that Sucraid will enable sucrose hydrolysis and the absorption of those hydrolysis products, glucose and fructose.
  • The effects of Sucraid have not been evaluated in patients with secondary (acquired) disaccharidase deficiency.
  • DO NOT HEAT SOLUTIONS CONTAINING SUCRAID. Do not put Sucraid in warm or hot fluids. Do not reconstitute or consume Sucraid with fruit juice since the acidity of the juice may reduce the enzyme activity of Sucraid. Half of the reconstituted Sucraid should be taken at the beginning of the meal or snack and the other half during the meal or snack.
  • Sucraid should be refrigerated at 36°F-46°F (2°C-8°C) and should be protected from heat and light.

Indication

Sucraid®(sacrosidase) Oral Solution is an enzyme replacement therapy for the treatment of genetically determined sucrase deficiency, which is part of Congenital Sucrase-Isomaltase Deficiency (CSID).